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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2590 | Vismodegib | Erivedge,GDC-0449,RG 3616 | Hedgehog/Smoothened , ABC , Autophagy |
Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM). |